Astrophysicists and physicists as creators of ArXiv-based commenting resources for their research communities. An initial survey

This paper conveys the outcomes of what results to be the first, though initial, overview of commenting platforms and related 2.0 resources born within and for the astrophysical community (from 2004 to 2016). Experiences were added, mainly in the physics domain, for a total of 22 major items, including four epijournals, and four supplementary resources, thus casting some light onto an unexpected richness and consonance of endeavours. These experiences rest almost entirely on the contents of the database ArXiv, which adds to its merits that of potentially setting the grounds for web 2.0 resources, and research behaviours, to be explored. Most of the experiences retrieved are UK and US based, but the resulting picture is international, as various European countries, China and Australia have been actively involved. Final remarks about creation patterns and outcome of these resources are outlined. The results integrate the previous studies according to which the web 2.0 is presently of limited use for communication in astrophysics and vouch for a role of researchers in the shaping of their own professional communication tools that is greater than expected. Collaterally, some aspects of ArXiv s recent pathway towards partial inclusion of web 2.0 features are touched upon. Further investigation is hoped for.Comment: Journal article 16 page

Challenging the Evidence Base: The Impact of Teen Pregnancy Prevention Curricula on Disconnected Youth

Rates of pregnancy and sexually transmitted infections are substantially higher for youth in foster care, juvenile detention, homeless shelters and substance use rehabilitation facilities. However, these "disconnected youth" face multiple barriers in accessing sexual health information. This study uses data from a multi-site federally funded project to examine the usefulness and effectiveness of teen pregnancy prevention evidence based programs (EBPs) with youth in high risk setting

Blogging astrophysics, shaping the self. Content-mediated Identity negotiation and peer group adjustment in a sample of astrophysicists’ blogs

This working paper was uploaded on SocArXiv on October 4th, 2021. As at April 26th, 2022 it was downloaded 55 times and got 166 views (source: SocArXiv).Research blogging has received a rather good amount of attention from the scholarly literature, but not in the domain of astrophysics. In the present paper, three active astrophysicists’ blogs have been chosen from a previously retrieved wider corpus and analyzed against the pivotal theory of identity shaping in an online setting. The study, which is essentially mixed-methods, has built on Susan Herring’s definition of computer-mediated conversation and focusses on content analysis as well as on content-based interaction (comments and replies per subject). Special care was taken on ensuring bloggers’ and commenters’ anonimity, in compliance with the British Psychological Society Ethics Guidelines. These blogs’ conversational capacity has emerged and the hypothesis of some degree of professional identity negotiation results to be confirmed, with implications on the invisible colleges. The context is that of an interdisciplinary, provisional junction between ground-based linguistic fieldwork in a 2.0 online setting and the search for appropriate theoretical frameworks about unconscious or semi-conscious aims of communication in a scholarly environment

Arxiv-based commenting resources by and for astrophysicists and physicists: an initial survey

This paper results to be the first, though absolutely initial, overview of commenting platforms and other web 2.0 resources which were born for and within the astrophysical research community, from 2004 to 2016. Additional experiences, chiefly in the physics domain, were added for a total of twenty-one tools, inclusive of four items in the specific area of epijournals – plus four supplementary resources which have been simply mentioned or anyway much more synthetically described due to their specific features –, thus casting some light onto an unexpected richness and consonance of endeavours. These experiences rest on the contents of the pioneering database ArXiv, which adds to its universally recognized merits that of setting the grounds for web 2.0 resources, and research behaviours, to be put in place

A mechanistic study on the cardiotoxicity of 5-fluorouracil in vitro and clinical and occupational perspectives

AbstractFluoropyrimidines are key agents for the treatment of gastrointestinal tract adenocarcinomas. The possible cardiotoxic effects in patients and occupationally exposed workers are multifactorial and remain a puzzle to solve for investigators. In the present study, we study what cell death pathways and what doses can determine direct cardiotoxic effects of 5-fluorouracil (5-FU) and doxorubicin (DOXO) on rat cardiocytes (H9c2) and a human colon adenocarcinoma (HT-29) cell line, already reported to be sensitive to 5-FU. We have found that 5-FU induced 50% growth inhibition (IC:50) at 72h with concentrations of 400μM and 4μM on H9c2 and HT-29, respectively. Moreover, we have found that the addition of Levofolinic Acid (LF) to 5-FU potentiated the growth inhibition induced by 5-FU. The growth inhibition induced by 5-FU alone or in combination with LF in cardiocytes was paralleled by an increase of thiobarbituric acid-reactive species (Tbars) and end products of nitric oxide (NO) suggesting the increase of the oxidative stress status in cardiocytes. Interestingly, these effects were strongly potentiated by the addition of LF, a biochemical modulator of 5-FU activity.Our data suggest that agents such as 5-FU different from anthracyclines, conventionally related to the induction of cardiotoxic effects, can also induce cardiocyte damage paralleled by oxidative stress. The strategies based upon the use of scavengers could be used in order to prevent this effect